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Inhibition by Methylprednisolone Acetate Suggests an Indirect Mechanism for TGF-B Induced Angiogenesis

 

作者: PhillipsGregg D.,   WhiteheadRussell A.,   KnightonDavid R.,  

 

期刊: Growth Factors  (Taylor Available online 1992)
卷期: Volume 6, issue 1  

页码: 77-84

 

ISSN:0897-7194

 

年代: 1992

 

DOI:10.3109/08977199209008873

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

AbstractAngiogenesis induced by transforming growth factor beta (TGFB) implanted in the rabbit cornea is accorripanied by an influx of inflammatory cells. To determine if the inflammatory cells are the mediators of the neovascularization, they were depleted by local administration of methylprednisolone acetate (MPA). Subconjunctival injections of 16 mg of MPA immediately following implantation of 50 ng of TGFB in the cornea prevented the inflammation and subsequent formation of capillaries. If the injections of MPA were delayed by 48 hr and the inflammatory cells were allowed to enter the cornea, angiogenesis occured, demonstrating that MPA had no adverse effects on the ability of endothelial cells to form capillaries. These results confirm the hypothesis that TGFB induces angiogenesis indirectly by recruiting inflammatory cells capable of stimulating direct angiogenesis.

 

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