Secretin‐dependent HCO3−secretion from pancreas and liver
作者:
T. GROTMOL,
T. BUANES,
T. VEEL,
M. RŒDER,
期刊:
Journal of Internal Medicine
(WILEY Available online 1990)
卷期:
Volume 228,
issue S732
页码: 47-51
ISSN:0954-6820
年代: 1990
DOI:10.1111/j.1365-2796.1990.tb01471.x
出版商: Blackwell Publishing Ltd
关键词: bile duct cell;H+‐ATPase;pancreatic duct cell
数据来源: WILEY
摘要:
Abstract.Ultrastructural studies performed on pigs revealed that numerous cytoplasmic tubulovesicles were present in resting pancreatic duct cells. Elevation of systemic arterial PCO2from 5.5 to 11 kPa increased the number of vesicles more than twofold. Following secretin administration, concurrent with the onset of HCO3−secretion (JHCO3). the cytoplasm became devoid of vesicles, and the basolateral plasma membrane surface area more than doubled. Similar phenomena were observed in bile duct cells. After pretreatment with the microtubulus‐inhibiting drug colchicine, secretin failed to reduce duct cell vesicle density, and JHCO3was reduced by c. 50% compared to the control. These ultrastructural changes resemble those described in other H+/HCO3−‐transporting organs such as the distal nephron and the urinary bladder. Our findings are compatible with the notion that cytoplasmic vesicles containing H+‐ATPases are incorporated into the basolateral plasma membrane of secretory cells during secretin stimulation. Active transport of H+into interstitial fluid might therefore be the driving force underly
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