Two-Kidney, One Clip Renal Hypertension in the Marmoset
作者:
Jeanette Wood,
Neelam Gulati,
Jean-Baptiste Michel,
Karl Hofbauer,
期刊:
Journal of Hypertension
(OVID Available online 1986)
卷期:
Volume 4,
issue 2
页码: 251-254
ISSN:0263-6352
年代: 1986
出版商: OVID
关键词: Blood pressure;converting enzyme inhibitor;marmoset;plasma renin activity;renal hypertension
数据来源: OVID
摘要:
The purpose of this study was to assess whether two-kidney, one clip (2K1C) renal hypertension can be induced in the marmoset. During the first 3-5 weeks after renal arterial clipping, blood pressure (BP) and plasma renin activity (PRA) increased in approximately one-third of the operated marmosets. However, within 10 weeks after clipping, BP and PRA had returned to control values. There was a significant positive correlation between BP and log PRA 3 and 5 weeks after the operation, but no correlation was observed at 10 weeks. In a selected group of marmosets with the highest values of BP (>140 mmHg; n=4), the converting enzyme inhibitor, enalapril (2 mg/kg s.c.) lowered BP by 58 ±7 (s.e.m.) mmHg when given 3 weeks after clipping. At 18 weeks the response to enalapril was only -17 ± 6 mmHg. These results demonstrate that unilateral renal arterial clipping in marmosets results in a transient renin-dependent hypertension. Marmosets in this initial hypertensive phase could be useful for investigating the antihypertensive effects of inhibitors of human renin.
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