首页   按分类浏览 期刊浏览 卷期浏览 A Convenient Synthesis of Centperazine, an Antifilarial Candidate Drug
A Convenient Synthesis of Centperazine, an Antifilarial Candidate Drug

 

作者: Sreela Sengupta,   Devi Prasad Sahu,   Sunil Krishna Chatterjee,  

 

期刊: Liebigs Annalen der Chemie  （WILEY Available online 1993）
卷期: Volume 1993, issue 4  

页码: 437-439

 

ISSN:0170-2041

 

年代: 1993

 

DOI:10.1002/jlac.199319930171

 

出版商: WILEY‐VCH Verlag

 

关键词: Centperazine;Antifilarial drug;6H‐Pyrazino[1,2‐c]pyrimidines

 

数据来源: WILEY

 

摘要:

Abstract7‐Ethyl‐octahydro‐2‐methyl‐6H‐pyrazino[1,2‐c]pyrimidin‐6‐one (centperazine) (1), an antifilarial candidate drug, currently undergoing phase II clinical trials, has been synthesized by a more economically viable alternative route. Condensation ofN,N′‐dibenzylethylenediamine (2) with 3,4‐dibromobutyronitrile (3) gives 2‐(1,4‐dibenzyl‐2‐piperazinyl)acetonitrile (4), which, on catalytic reduction, debenzylation, cyclocarbamation andN‐alkylation yields the targe

 

点击下载:  PDF (278KB)



返 回