Cerebral Perfusion Pressures (CPP) and GlasgowComaScale (GCS) scores were monitored to guide the management of severely head-injured patients. These measures were correlated to outcome (GlasgowOutcomeScale-GOS) in 136 consecutive patients at least 1 year after injury. The GOS showed highly significant positive correlations to either CPP or GCS assessments (p<0.001). Two parameters that are correlated with subsequent death in most patients include 1) highest (h) GCS = 3 or 4 (Day 1: 31 of 32 patients died, and Day 2: 19 of 19 patients died), and 2) CPP ≤60 mm Hg more than 33% of the hourly measures during Day 2 (36% of all subsequent deaths; 11% overlap with the highest Glasgow Coma Scale). The Day 2 measures identifying two groups that have a >75% incidence of “good outcome” or GOS = 4 or 5 include 1) hGCS ≤6 (N= 45) and 2) the average (a) CPP ≥90 mm Hg (N= 26). Of the 45 patients with a GOS = 4 or 5 who had both CPP and GCS recorded on the third day, 44 were identified by these “good outcome” parameters.