Clinical Pharmacokinetics During Continuous Ambulatory Peritoneal Dialysis
作者:
Claude A. Taylor,
Emaad Abdel-Rahman,
Stephen W. Zimmerman,
Curtis A. Johnson,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1996)
卷期:
Volume 31,
issue 4
页码: 293-308
ISSN:0312-5963
年代: 1996
出版商: ADIS
数据来源: ADIS
摘要:
Peritoneal dialysis (PD) has gained recognition worldwide as an alternative to haemodialysis in the management of patients with end-stage renal disease. Because the peritoneal catheter provides direct access to the peritoneum, intraperitoneal drug administration has become widely used for the administration of certain drugs. The instillation and drainage of PD fluids contribute to the total body clearance of drugs given by other routes. For most drugs, peritoneal clearance is low.This paper provides an updated review of recently published pharmacokinetic studies involving the administration of selected drugs to patients receiving PD. Antibiotics continue to be extensively studied and administered in PD patients because of the frequent occurrence of infections. Epoetin (recombinant human erythropoietin) has become widely used and is the subject of ongoing pharmacokinetic investigation. Intraperitoneal insulin has become accepted for the treatment of patients with diabetes receiving PD; the pharmacokinetics of vitamin D analogues in PD patients continue to be explored.
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