AbstractVertebral and radial anomalies are prominent features of VATERvertebral defects,anorectal anomaly,tacheoesophageal fistula with esophageal atresia, andradial dysplasia association. It has been shown that exposure of the rat fetus to adriamycin produces a spectrum of anomalies, including esophageal atresia and other features of VATER association. We aimed to document the skeletal defects found in rats exposed to teratogenic doses of adriamycinin utero. Vertebral, rib. and limb anomalies were found in 54, 54, and 35% of these examined fetuses, respectively. The range of bone lesions seen in this animal model was similar to the range of lesions seen in infants born with VATER association.