Urinary Excretion of Valproate and Some Metabolites in Chronically Treated Patients
作者:
Ronald Dickinson,
Wayne Hooper,
Paul Dunstan,
Mervyn Eadie,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 2
页码: 127-133
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Valproate metabolism;Epileptic patients;Chronic treatment;Urinary recovery.
数据来源: OVID
摘要:
Urinary excretion of the antiepileptic agent valproic acid (VPA) and major metabolites from its glucuronidation, β-oxidation, and ω- and ω1-hydroxylation pathways were studied under steady state conditions in 24 epileptic patients. Some 55 \pm 18% (SD) of the daily dose was recovered in urine, 33 \pm 14% in the form of VPA-glucuronide, 15 \pm 8% as β-oxidation products, and 4 \pm 2% and 2 \pm 1% as products of the ω- and ω1-hydroxylation pathways, respectively. Only 1 \pm 2% of the dose was excreted unchanged. The proportion metabolized by direct glucuronidation tended to increase with dose at the expense of the oxidative pathways, particularly β-oxidation. However, the wide variation in the patterns of urinary metabolite excretion precludes use of routinely collected urinary excretion data as a basis for detecting any but severe noncompliance with VPA therapy or abnormalities of VPA metabolism.
点击下载:
PDF
(488KB)
返 回