The renal cell primary cilium functions as a flow sensor
作者:
Helle Praetorius,
Kenneth Spring,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 2003)
卷期:
Volume 12,
issue 5
页码: 517-520
ISSN:1062-4821
年代: 2003
出版商: OVID
数据来源: OVID
摘要:
Purpose of reviewTo discuss recent reports on the function and importance of the renal primary cilium, a widely distributed organelle.Recent findingsMost epithelial cells, including those in the kidney, express a solitary primary cilium. The primary cilium functions as a flow sensor in cultured renal epithelial cells (MDCK and mouse collecting tubule) mediating a large increase in intracellular calcium concentration. Flow sensing is shown to reside in the cilium itself and to involve the proteins polycystin 1 and 2, defects in which are associated with the majority of cases of human polycystic kidney disease. The role of the cilium in flow-dependent potassium secretion by the collecting tubule and in sensing of chemical components of the luminal fluid are also described.SummaryThe primary cilium is mechanically sensitive and serves as a flow sensor in cultured renal epithelia. Bending the cilium by mechanical means or flow causes a large, prolonged transient increase in intracellular calcium. The mechanically sensitive protein in the cilium is a polycystin.
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