PATHOGENESIS AND PREVENTION OF GRAFT ARTERIOSCLEROSIS IN AN EXPERIMENTAL HEART TRANSPLANT MODEL
作者:
KEITH LURIE,
MARGARET BILLINGHAM,
STUART JAMIESON,
DONALD HARRISON,
BRUCE REITZ,
期刊:
Transplantation
(OVID Available online 1981)
卷期:
Volume 31,
issue 1
页码: 41-47
ISSN:0041-1337
年代: 1981
出版商: OVID
数据来源: OVID
摘要:
Accelerated graft arteriosclerosis is a major cause of death in human heart transplantation. Despite many investigations, the pathogenesis of this disease remains undetermined and its control inadequate. In this study using a rat heart transplant model and cyclosporin A, a new immunosuppressant, acute rejection was prevented but arteriosclerotic-like vessel disease still developed consistently as early as 20 days postoperatively. The combination of cyclosporin A and dipyridamole prevented the development of this vessel disease in transplanted hearts at 20 and 50 days postoperatively. Sulfinpyrazone and cyclosporin A reduced but did not prevent the disease. These findings suggest that immunologically induced graft arteriosclerosis can be prevented in transplanted rat hearts by the combination of cyclosporin A and dipyridamole.
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