Neurotrophic effects of GABA in cultures of embryonic chick brain and retina
作者:
P. E. Spoerri,
期刊:
Synapse
(WILEY Available online 1988)
卷期:
Volume 2,
issue 1
页码: 11-22
ISSN:0887-4476
年代: 1988
DOI:10.1002/syn.890020104
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Differentiation;Synaptogenesis
数据来源: WILEY
摘要:
AbstractThe present study examined whether GABA treatments would affect the growth and development of embryonic chick cortical and retinal neurons in culture. Incubation of these cells in the presence of 10−−5M GABA produced several responses. It promoted the proliferation and the differentiation of the neurons studied by affecting the length and branching of the neurites as well as synaptogenesis, as revealed by morphometric measures. At the ultrastructural level, GABA treatment also led to an increased density of neurotubules, rough endoplasmic reticulum (RER), Golgi apparatus, coated vesicles, and other vesicles. These data support the hypothesis that GABA functions as a trophic or regulatory factor of at least certain neuron ty
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