Association of Diurnal Variations in Hypothalamic but Not Cortical Opiate ([3H]-Naloxone)-Binding Sites with the Ability of Naloxone to Induce LH Release in the Prepubertal Female Rat
作者:
William Jacobson,
Michael Wilkinson,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 44,
issue 1
页码: 132-135
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124634
出版商: S. Karger AG
关键词: Opiate binding;LH release;Diurnal rhythms;Hypothalamus
数据来源: Karger
摘要:
We report the existence of a diurnal variation in the binding of the opiate antagonist [3H]-naloxone to slices of the mediobasal hypothalamus from prepubertal female rats. The binding is highest in the early morning and reaches a nadir in the late afternoon. Opiate binding in cortical slices from such animals is constant over the course of the day. Changes in receptor density, and not in receptor affinity, account for the diurnal variation in the amount of ligand bound. These diurnal variations in receptor numbers are associated with changes in the ability of naloxone to release LH and may be crucial in the transition from the juvenile state to one of competent reproductive functioning.
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