Effect of Rate of Enteral Nutrient Supply on Gut Mass
作者:
Gary P. Zaloga,
Kimberly Ward Black,
Richard Prielipp,
期刊:
Journal of Parenteral and Enteral Nutrition
(WILEY Available online 1992)
卷期:
Volume 16,
issue 1
页码: 39-42
ISSN:0148-6071
年代: 1992
DOI:10.1177/014860719201600139
出版商: SAGE Publications
数据来源: WILEY
摘要:
Early enteral feeding after injury is important for maintenance of gut integrity. However, enteral nutrients are frequently administered at low rates because of decreased gastrointestinal motility. These low rates are said to “maintain the gut.” This study was performed to evaluate the effect of rate of enteral nutrient delivery on gut mass.Six male Sprague‐Dawley rats had no surgery and served as controls (ad libitumrat chow diet). Twenty‐four male Sprague‐Dawley rats underwent abdominal surgery for placement of gastroduodenal feeding tubes (tip located 2 cm into intestine from pylorus) and were randomized (n = 6 per group)to ad libitumrat chow, 1/2 strength peptide diet (Reabilan HN, RHN) at 1 mL/h (1/2RHN‐1 mL), full‐strength peptide diet at 2 mL/h (RHN‐2 mL), or full‐strength peptide diet at 4 mL/ h (RHN‐4 mL). These diets supplied approximately 30%, 13%, 50%, and 100% of rat recommended daily allowances.The control animals gained weight (38 ± 3 g over 5 days) whereas all postsurgery animals lost weight. Weight loss was greatest in the 1/2 RHN‐1 mL (‐55 ± 3 g over 5 days) and RHN‐2 mL (‐52 ± 6 g over 5 days) groups compared with the RHN‐4 mL animals (‐41 ± 5 g over 5 days). All animals fed liquid enteral diets had reduced gut weights compared with chow‐fed animals. Gut weights did not differ between control and postsurgeryad libitumchow animals. Proximal gut mucosal protein content was significantly (p<.05) higher in the RHN‐4 mL animals (0.88 ± 0.03 mg/cm) compared with control (0.74 ± 0.003 mg/cm) andad libitumchow animals (0.73 ± 0.05 mg/ cm). There were no differences in mid‐ and distal gut mucosal protein levels between groups. We conclude that the rate of enteral feeding has little effect on gut mass in the early (5 day) postoperative period in rats. (Journal of Parenteral and Enteral Nutrition16:39–42, 1992)
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