Toxic Acute Renal Failure in the Rat: Effects of Diltiazem and Urodilatin on Renal Function
作者:
L. Schramm,
E. Heidbreder,
J. Schaar,
K. Lopau,
J. Zimmermann,
R. Götz,
H. Ling,
A. Heidland,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 68,
issue 4
页码: 454-461
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188307
出版商: S. Karger AG
关键词: Acute renal failure;Diltiazem;Urodilatin;Glomerular filtration rate;Renal function
数据来源: Karger
摘要:
Beneficial effects of natriuretic peptides have been reported in different models of acute renal failure (ARF). Calcium antagonists can also improve renal function, especially in ischemic models of ARF. The aim of our study was to investigate the effects of urodilatin and diltiazem alone and in combination in uranyl nitrate-induced toxic ARF in the rat. Three hours after induction of ARF glomerular filtration rate (GFR) was clearly diminished to about 50% compared to basal values. Intravenous infusion of diltiazem and urodilatin revealed a significant increase of GFR that even continued after cessation of drug delivery. Combined administration of urodilatin and diltiazem had no additional effect, probably due to a more pronounced fall in blood pressure in this group. Besides their vasorelaxing and blood pressure lowering effects both drugs also revealed diuretic activity. In conclusion both urodilatin and diltiazem are able to elevate GFR in the early phase of toxic ARF in the rat.
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