T cell adhesion molecules
作者:
Barbara E. Bierer,
Steven J. Burakoff,
期刊:
The FASEB Journal
(WILEY Available online 1988)
卷期:
Volume 2,
issue 10
页码: 2584-2590
ISSN:0892-6638
年代: 1988
DOI:10.1096/fasebj.2.10.2838364
出版商: Wiley
数据来源: WILEY
摘要:
Cell adhesion or conjugate formation between T lymphocytes and other cells is an important early step in the generation of the immune response. Although the antigen‐specific T cell receptor confers antigen recognition and specificity, a number of other molecules expressed on the T cell surface are involved in the regulation of lymphocyte adhesion. T cell molecules that function to strengthen adhesion include lymphocyte function‐associated antigen (LFA)‐1, CD2, CD4, and CD8. Their ligands have recently been identified. LFA‐1 is a member of the integrin family of adhesion receptors and one of its ligands is intercellular adhesion molecule‐1 (ICAM‐1); a ligand for CD2 is LFA‐3; and ligands for CD4 and CD8 appear to be major histocompatibility complex class II and class I molecules, respectively. In addition, T cells express a number of receptors thought to be involved in cell matrix adhesion. The function and significance of these T cell adhesion receptors and their ligands are reviewed.—Bierer, B. E.; Burakoff, S. J. T cell adhesion molecules.FASEBJ.2: 2584‐2590; 1988.
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