Description of the statistical aspects of a study for advanced colorectal cancer patients
作者:
Samuel Wieand,
Stephen Cha,
期刊:
Statistics in Medicine
(WILEY Available online 1992)
卷期:
Volume 11,
issue 1
页码: 5-11
ISSN:0277-6715
年代: 1992
DOI:10.1002/sim.4780110103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractA screening design was used in a trial that compared a standard regimen to five experimental regimens for the treatment of advanced colorectal cancer where the endpoint was survival. The two‐stage design permitted the termination of accrual to experimental regimens that failed to show promise at the first stage. It also allowed for termination of accrual to the standard regimen if an experimental regimen appeared to offer a highly significant improvement over the standard regimen. This paper presents a description of the design and the results of the tria
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