The clinical and imaging features of four dogs with Cushing's syndrome and pulmonary mineralization are reviewed. Three dogs presented with a primary complaint of respiratory distress/dyspnea. Three dogs had pituitary dependent Cushing's syndrome, while the remaining one dog had iatrogenic Cushing's syndrome. Each dog had clinical features typical for Cushing's syndrome. Two of the dogs were euthanized due to progressive hypoxemia. In each dog, the serum calcium, phosphorous, blood urea nitrogen and creatinine were normal.A generalized increase in unstructured interstitial pulmonary opacity with diffuse mineralization was noted on thoracic radiographs of all dogs. In one dog, an ill‐defined nodular interstitial pattern of mineralization was present. Delayed bone phase scintigraphy using99mTechnetium methylene diphosphonate documented generalized pulmonary uptake in two dogs.99mTechnetium labeled microaggregated albumin lung perfusion scans were normal in these two dogs.99mTc‐MDP scintigraphy can provide useful information in diagnosing pulmonary mineralization in Cushingoid d