Late Endocrine Effects of Administering Monosodium Glutamate to Neonatal Rats
作者:
J.L. Bakke,
N. Lawrence,
J. Bennett,
S. Robinson,
C.Y. Bowers,
期刊:
Neuroendocrinology
(Karger Available online 1978)
卷期:
Volume 26,
issue 4
页码: 220-228
ISSN:0028-3835
年代: 1978
DOI:10.1159/000122829
出版商: S. Karger AG
关键词: Monosodium glutamate;Neonatal rats;Pituitary hormones;Hypo-thalamic lesion;Obesity;Fertility
数据来源: Karger
摘要:
Rats were injected with monosodium 1-glutamate (MSG) daily for the 1st 5 days of life and allowed to mature. This is known to cause selective destruction of neurons in the retina and in the arcuate nucleus of the hypothalamus. The adult animals had a significant increase in body fat without an increase in weight, a marked reduction in pituitary, thyroid, adrenal, gonadal and prostate weights. Pituitary, hypothalamic and serum thyrotropin (TSH) were significantly reduced in the males. Serum growth hormone (GH) was markedly reduced in both sexes and the serum prolactin (Prl) was increased significantly in females. FSH did not appear to be abnormal and the LH may have been increased in the males. Serum T4 was significantly reduced in females. The fertility of the females was normal, but treated males mated with normal females showed a marked reduction in fertility and, although the litter sizes of the offspring were normal, the birth weights of the pups of both sexes were significantly reduced. These persistent alterations in neuroendocrine function indicate that lesions produced by neonatal MSG treatment provide a convenient model for studying hypothalamic function.
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