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Biperiden and Haloperidol Plasma Levels and Extrapyramidal Side Effects in Schizophrenic Patients

 

作者: Kurt Meszaros,   Elisabeth Lenzinger,   Kurt Hornik,   Georg Schönbeck,   Reinhold Hatzinger,   Gerhard Langer,   Werner Sieghart,   Harald N. Aschauer,  

 

期刊: Neuropsychobiology  （Karger Available online 1997）
卷期: Volume 36, issue 2  

页码: 69-72

 

ISSN:0302-282X

 

年代: 1997

 

DOI:10.1159/000119365

 

出版商: S. Karger AG

 

关键词: Biperiden plasma levels;Haloperidol plasma levels;Relation between dose and plasma levels;Extrapyramidal side effects;Chronic schizophrenia

 

数据来源: Karger

 

摘要:

Anticholinergic drugs such as biperiden are used for the treatment of extrapyramidal side effects (EPS) induced by neuroleptics such as haloperidol. The effects of biperiden and haloperidol plasma levels on EPS were studied in 29 chronically ill schizophrenics. The results show relationships between biperiden dose and biperiden plasma levels (BPL), and between BPL and haloperidol plasma levels (HPL). Neither BPL nor HPL seem to influence EPS.

 

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