Summary1A case of chlorpromazine induced jaundice is described together with the laboratory findings.2The literature relating to the etiology and pathogenesis of the condition is briefly reviewed.3Reasons are advanced for attempting to avoid surgery in these cases.4It is suggested that puncture biopsy of the liver be performed in order to obtain this end.5It is further suggested that in prolonged jaundice treatment with A.C.T.H. or cortisone be instituted.