This is the second of a two part series. In this issue, Part II presents the therapeutic results of hepatic artery ligation and infusion chemotherapy (either IA hepatic or IV portal), radiotherapy (either external or internal), and the newer techniques of transcatheter embolization, hyperthermia, etc., are reviewed. The outcome of many recent studies using various combinations of the above regional modalities are presented. The most effective permutation and combination of drugs remains to be determined by future clinical trials.