Dietary nucleotide effects upon murine natural killer cell activity and macrophage activation
作者:
JD Carver,
WI Cox,
LA Barness,
期刊:
Journal of Parenteral and Enteral Nutrition
(WILEY Available online 1990)
卷期:
Volume 14,
issue 1
页码: 18-22
ISSN:0148-6071
年代: 1990
DOI:10.1177/014860719001400118
出版商: SAGE Publications
数据来源: WILEY
摘要:
Weanling mice fed chow or chow plus water supplemented with 3.5 mg of nucleotides per 100 ml of water for 6 weeks exhibited increased natural killer cell (NK) activity and lower macrophage activation compared to mice fed chow plus nonsupplemented water. In a dose‐response study, NK activity, macrophage activation and spleen weight (as a percentage of body weight) were higher in mice fed up to 0.035% w/w nucleotides, however macrophage activation was decreased by feeding over 0.35% w/w compared to those receiving basal purified diet (BPD). Nucleotides in human milk may affect the immune response in breast‐fed infants.
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