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A Vaccine for Multiple SclerosisIs it a Feasible Option?

 

作者: Dennis N. Bourdette,  

 

期刊: CNS Drugs  (ADIS Available online 1996)
卷期: Volume 5, issue 1  

页码: 1-7

 

ISSN:1172-7047

 

年代: 1996

 

出版商: ADIS

 

数据来源: ADIS

 

摘要:

Multiple sclerosis is an immune-mediated disease of the CNS, and T cells appear to play a central role in its pathogenesis. In an animal model, T cells specific for myelin basic protein (MBP) induce a syndrome (experimental autoimmune encephalomyelitis) with symptoms similar to multiple sclerosis. This suggests that T cells specific for this protein may be pathogenic in multiple sclerosis.Anti-T cell vaccines that induce regulation of autoreactive T cells are effective treatments for experimental autoimmune encephalomyelitis. These anti-T cell vaccines include whole T cell vaccination, T cell receptor peptide immunisation, oral administration of myelin antigens and major histocompatibility complex (MHC) class II peptide immunisation.Preliminary experience in patients who have multiple sclerosis with the first 3 approaches suggests that anti-T cell vaccines represent feasible treatments for this disorder.

 

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