AgNOR mark epithelial foci in malignant transformation in hamster cheek pouch carcinogenesis
作者:
A. E. Schwint,
A. Folco,
A. Morales,
R. L. Cabrini,
M. E. Itoiz,
期刊:
Journal of Oral Pathology&Medicine
(WILEY Available online 1996)
卷期:
Volume 25,
issue 1
页码: 20-24
ISSN:0904-2512
年代: 1996
DOI:10.1111/j.1600-0714.1996.tb01218.x
出版商: Blackwell Publishing Ltd
关键词: AgNOR;carcinogenesis;DMBA;hamster cheek pouch;nucleolar organizer regions
数据来源: WILEY
摘要:
Hamster cheek pouch mucosa is an accepted model of oral carcinogenesis. We herein examined the value of morphometric evaluation of silver‐stained nucleolar organizer regions (AgNOR) in the detection of epithelial foci in malignant transformation following dimethyl‐1, 2‐benzanthracene‐induced carcinogenesis of hamster cheek pouch. AgNOR‐related parameters were analyzed at different stages of the process of carcinogenesis (control epithelium, epithelium with no unusual microscopic features, “dysplastic” epithelium, exophytic and endophytic carcinomas). Morphometric evaluation of AgNOR revealed incipient cellular alterations which were not evident in routine preparations and contributed to the characterization of different stages of carcinogenesis
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