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Translocation, t(17;22)(q22;q13), in dermatofibrosarcoma protuberans: a new tumor-assoc...
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Translocation, t(17;22)(q22;q13), in dermatofibrosarcoma protuberans: a new tumor-associated chromosome rearrangement
作者:
F. Pedeutour,
M.P. Simon,
F. Minoletti,
G. Barcelo,
M.J. Terrier-Lacombe,
P. Combemale,
G. Sozzi,
N. Ayraud,
C. Turc-Carel,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1996)
卷期:
Volume 72,
issue 2-3
页码: 171-174
ISSN:1424-8581
年代: 1996
DOI:10.1159/000134178
出版商: S. Karger AG
数据来源: Karger
摘要:
A translocation, t(17;22)(q22;ql 3), was identified in two cases of dermatofibrosarcoma protuberans (DP). They bring to four the number of DP cases characterized by an identical t(17;22)(q22;q13), which can be considered as a new tumor-associated chromosome rearrangement. To date, this translocation has been found only in DP and its juvenile form, giant-cell fibroblastoma. This finding has two major consequences. First, it casts light on the development and significance in DP of ring chromosomes which consistently harbor sequences derived from chromosomes 17 and 22. Second, the identification of this new chromosome marker, and eventually of the underlying molecular rearrangement, should help to classify DP, a soft-tissue tumor of still uncertain cell origin. In addition, it could be used to differentiate DP from truly benign or malignant entities, in order that this tumor of intermediate malignancy could be adequately managed.
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