Effect of Donor Age on Clonal Differentiation of Human Skin Fibroblasts in vitro
作者:
Martina Steinhardt,
期刊:
Gerontology
(Karger Available online 1985)
卷期:
Volume 31,
issue 1
页码: 27-38
ISSN:0304-324X
年代: 1985
DOI:10.1159/000212678
出版商: S. Karger AG
关键词: Human skin fibroblasts;Cytodifferentiation in vitro;Clone types;Clone size;Limited division capacity;Cell aging in vivo and in vitro
数据来源: Karger
摘要:
Human skin fibroblasts of about the same population doubling level, derived from donors of different age, were cloned. After 14 days of growth, the clones were morphologically classified, and cell counts were performed. Significant differences between the three age groups (infant, young adult, old adult) examined concerned the percentual clone type distribution. The size of a single clone depended on the clone type referring to the differentiation level of the cells in all age groups.
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