New developments in microscale separations and mass spectrometry for biomonitoring: Capillary electrophoresis and electrospray ionization mass spectrometry
作者:
R. D. Smith,
J. H. Wahl,
K. J. Light‐Wahl,
B. E. Winger,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1993)
卷期:
Volume 40,
issue 2-3
页码: 147-158
ISSN:0098-4108
年代: 1993
DOI:10.1080/15287399309531783
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
In this article, we briefly highlight the use of capillary electrophoresis for sampling, manipulating, and separating extremely small sample sizes. The extraordinary sensitivity that can be obtained by combined capillary electrophoresis‐mass spectrometry is then demonstrated using recent results. We briefly describe the ability to detect noncovalently associated complexes (e.g., double‐stranded DNA) by electrospray ionization‐mass spectrometry, and conclude with recent results that show the potential for using high‐resolution Fourier transform ion cyclotron resonance (FT‐ICR) mass spectrometry for characterization of biomolecules.
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