EVIDENCE FOR DIFFERING DOPAMINERGIC ACTIVITY IN CHILDHOOD‐ OR ADULT‐ONSET OBESITY
作者:
ANNA CATANIA,
L. CANTALAMESSA,
EMANUELA VENEGONI,
ALESSANDRA ORSATTI,
MARINA BALDINI,
C. ZANUSSI,
期刊:
Clinical Endocrinology
(WILEY Available online 1985)
卷期:
Volume 22,
issue 1
页码: 75-81
ISSN:0300-0664
年代: 1985
DOI:10.1111/j.1365-2265.1985.tb01067.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SUMMARYIn order to investigate dopaminergic activity in two types of human obesity, childhood‐ and adult‐onset, we have studied the responses of plasma TSH and prolactin to domperidone, a dopamine receptor antagonist, in 12 patients obese since early childhood, 12 patients with adult‐onset obesity, and in 12 lean controls. All subjects were females. In childhood‐onset obese patients the responses of plasma prolactin and TSH to antidopaminergic stimulation were lower than those of adult‐onset obese patients and lean controls. Conversely, the stimulus elicited a normal response of plasma prolactin and an exaggerated response of plasma TSH in adult‐onset obese patients. These data indicate the presence of differing dopaminergic tone in the two types of hu
点击下载:
PDF
(366KB)
返 回