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Characterization of the Fibrinolytic State by Measuring Stable Cross-Linked Fibrin Degradation Products in Disseminated Intravascular Coagulation Associated with Acute Promyelocytic Leukemia

 

作者: Kenji Okajima,   Shin Koga,   Hiroaki Okabe,   Masayasu lnoue,   Kiyoshi Takatsuki,  

 

期刊: Acta Haematologica  （Karger Available online 1989）
卷期: Volume 81, issue 1  

页码: 15-18

 

ISSN:0001-5792

 

年代: 1989

 

DOI:10.1159/000205392

 

出版商: S. Karger AG

 

关键词: Acute promyelocytic leukemia;α2-plasmin inhibitor;Cross-linked fibrin degradation products;Disseminated intravascular coagulation;Fibrinogenolysis;Fibrinolysis

 

数据来源: Karger

 

摘要:

Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than samples of DIC with non-APL. The difference between FDP(D) and XDP levels increased only when α2-plasmin inhibitor (α2-PI) fell below 60% of the normal level in APL patients. These findings suggest that fibrinogenolysis occurs in APL patients when the α2-PI level has decreased significant

 

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