Platelet Dysfunction in Acute Megakaryoblastic Leukemia
作者:
Enrico M. Pogliani,
Mariangela Colombi,
Elisabetta Cofrancesco,
Marco Salvatore,
Camilla Fowst,
期刊:
Acta Haematologica
(Karger Available online 1989)
卷期:
Volume 81,
issue 1
页码: 1-4
ISSN:0001-5792
年代: 1989
DOI:10.1159/000205389
出版商: S. Karger AG
关键词: Megakaryoblastic leukemia;Prostaglandin pathway;Release reaction;Thrombocytopathy
数据来源: Karger
摘要:
Platelet function profiles were studied in 3 patients with megakaryoblastic leukemia. All patients had a moderate decrease in platelet counts with abnormal platelet retention. One patient who developed hemorrhagic diathesis had prolonged bleeding time. In all patients platelet aggregation was defective after the addition of ADP, collagen, adrenaline, or U46619, athromboxane A2 agonist. Malondialdehyde was reduced in all patients, as was platelet serotonin. Plasma β-thromboglobulin levels were normal in all cases whereas PF4 was markedly elevated in one. Platelet dysfunction was not reversed by clinical remission. These studies confirm that megakaryoblastic leukemia is associated with a thrombocytopathy which may play a role in hemorrhagic diathesis and should be taken into account in the management of these patients
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