Hereditary Diabetes insipidus in Rats
作者:
G.L. Kovács,
G. Szabó,
L. Szontágh,
L. Medve,
G. Telegdy,
F.A. László,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 31,
issue 3
页码: 189-193
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123072
出版商: S. Karger AG
关键词: Diabetes insipidus;Serotonin;Noradrenaline;Dopamine
数据来源: Karger
摘要:
Compared to heterozygous Brattleboro animals, homozygous (diabetes insipidus) rats exhibited higher steady-state levels of serotonin in the mesencephalon, septum and striatum. These differences disappeared upon the administration of pargyline, suggesting a decreased accumulation of serotonin. The norepinephrine level was higher in the mesencephalon, while the disappearance rate (α-methyl-p-tyrosine) was accelerated in the septum and decreased in the hypothalamus. The lower striatal dopamine level was associated with a decreased disappearance rate. The data suggest that the altered monoamine metabolism might be associated with the known endocrine and behavioral disturbances of the homozygous rats
点击下载:
PDF
(886KB)
返 回