Relationship between Cancer Slope Factor and Acute Toxicity in Rats and Fish
作者:
Damon Delistraty,
期刊:
Human and Ecological Risk Assessment: An International Journal
(Taylor Available online 1999)
卷期:
Volume 5,
issue 2
页码: 415-426
ISSN:1080-7039
年代: 1999
DOI:10.1080/10807039991289518
出版商: TAYLOR & FRANCIS
关键词: risk assessment;prediction;human equivalent dose;carcinogenic potency;acute lethality
数据来源: Taylor
摘要:
The purpose of this study was to examine bivariate relationships among cancer slope factor (CSF) and acute toxicity in rats and salmonid fish. Chemicals (n=43) were selected based on the availability of both oral CSF and acute toxicity data (rat oral median lethal dose [LD50] or salmonid median lethal concentration [LC50]). Rat oral LD50, salmonid LC50, and oral CSF data were log-transformed, and a Bonferroni-adjusted alpha level was set at 0.05 for subsequent correlation analysis. A significant correlation was observed between CSF and rat oral LD50 (r=−0.61) but not for CSF and salmonid LC50 (r=−0.29). Moreover, rat and fish acute toxicity were not significantly correlated (r=0.38). The significant correlation between CSF and rat oral LD50 compares favorably with published results reported in related studies. Accordingly, these results support prediction of carcinogenic potency, expressed as oral CSF, based in part on acute toxicity in rats.
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