First Derivative Spectrophotometric Determination of Phenytoin
作者:
Abdel-AzizM. Wahbi,
ArafatM. Al-julani,
期刊:
Analytical Letters
(Taylor Available online 1985)
卷期:
Volume 18,
issue 11
页码: 1375-1380
ISSN:0003-2719
年代: 1985
DOI:10.1080/00032718508066217
出版商: Taylor & Francis Group
关键词: Phenytoin;Diphenylhydantion;First-derivative spectro-photometry;Determination;Tablets and Capsules.
数据来源: Taylor
摘要:
The first derivative curve (D1) of absorption spectrum of Phenytoin in buffer pH 10 develos negative peaks at 244, 263 and 270 nm. D1at 244 nm was found linearly related to concentration over a range 0.4 − 1.4 mg per 100 ml and highly reproducible (C.V. %=0.62). Tablets and capsules have been analyzed using D1at 244 nm and the mean percentage found were 99.7 ± 0.81 and 103.3 ± 0.44, respectively. The B.P. method gave 100.9 and 103.8 %, respectively.
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