MICROSCOPIC AND MACROSCOPIC DESCRIPTIONS OF GAS AND AEROSOL TRANSPORT IN THE HUMAN LUNG
作者:
R. P. BATYCKY,
D. A. EDWARDS,
期刊:
Chemical Engineering Communications
(Taylor Available online 1996)
卷期:
Volume 148-150,
issue 1
页码: 23-39
ISSN:0098-6445
年代: 1996
DOI:10.1080/00986449608936506
出版商: Taylor & Francis Group
关键词: Aerosol;Transport;Human lung;Microscopic and macroscopic
数据来源: Taylor
摘要:
This article discusses the validity of describing single-breath, gas or aerosol bolus transport processes in terms of effective Gaussian characteristics. This is done in the context of a comparison between the predictions of a recent macrotransport model or pulmonary transport phenomena and predictions based upon the numerical solution of a so-called ‘exact’ microtransport problem, in addition, comparison is made with the predictions of a former network model of convective dispersion in the conducting airways of the lung. For conditions of physiological interest, the macrotransport model is shown to predict to within reasonable accuracy the mode (i.e., time of exit of the peak of an inspired bolus) as well as the dispersion of gas or aerosol for the case of an impulsive introduction of the gas/aerosol bolus (varying the shape and size of the bolus). The relative merits of micro- and macroscopic descriptions of lung transport problems are discussed. Comparisons with experimental data, as well as a discussion of the implications of the present study on the future development of transport models of lung dispersion, are provided.
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