Ontogeny of the Immune System: Fetal Lamb as a Model
作者:
RUKMANI RAGHUNATHAN,
MICHAEL MILLER,
CARLA WUEST,
JUDY FAUST,
期刊:
Pediatric Research
(OVID Available online 1984)
卷期:
Volume 18,
issue 5
页码: 451-456
ISSN:0031-3998
年代: 1984
出版商: OVID
关键词: BSA, bovine serum albumin;CCE, counterflow centrifugation elutriation;CPM, counts/min;EA, antibody-coated sheep red cells;EAC, antibody-and complement-coated sheep red cells;FeIgG, Fc portion of IgG;FITC, fluorescein isothiocyanate;FITC F(ab)2RxSIg, FETC
数据来源: OVID
摘要:
SummaryWe examined adult sheep lymphocytes for the following surface markers: Surface membrane immunoglobulin, antigen identified by anti-sheep thymocyte globulin and complement receptors. We quantitated sheep peripheral blood mononuclear leukocyte proliferative responses to mitogens and alloantigens, and demonstrated a neutrophil-directed chemotactic factor (NLDCF) liberated by mitogen-stimulated sheep mononuclear cells. A comparison of adult and fetal sheep from 120-150 d of gestation demonstrated that/) fetal sheep had adult proportions of surface membrane Ig+ and T+ lymphocytes but a significant decrease in FcIgG receptor+ lymphocytes, 2) proliferative responses of fetal sheep blood mononuclear cells to mitogens and alloantigens were comparable to adult responses, and 3) fetal mononuclear leukocytes failed to produce the lymphokine, NLDCF, in response to mitogen stimulation.
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