Secretion of drugs in tears
作者:
Van HaeringenN. J.,
期刊:
Current Eye Research
(Taylor Available online 1985)
卷期:
Volume 4,
issue 4
页码: 485-488
ISSN:0271-3683
年代: 1985
DOI:10.3109/02713688509025164
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Secretion in tears has been investigated for a limited number of drugs. Transfer of the free non protein-bound fraction from plasma to tears only can be expected for unionized drugs with sufficient lipid solubility. For acid and basic drugs the correlation of tear: plasma (unbound) ratio is disturbed by variations in tear pH.Within these limitations tear sampling will not be an useful method for drug concentration measurement.
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