A simplified technique for in vivo analysis of sister-chromatid exchanges using 5-bromodeoxyuridine tablets
作者:
J.W. Allen,
C.F. Shuler,
R.W. Mendes,
S.A. Latt,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1977)
卷期:
Volume 18,
issue 4
页码: 231-237
ISSN:1424-8581
年代: 1977
DOI:10.1159/000130765
出版商: S. Karger AG
数据来源: Karger
摘要:
A small tablet of 5-bromodeoxyuridine (BrdU), implanted subcutaneously in a mouse, provides sustained release of base analog sufficient to effect substitution of DNA throughout an entire replication period. As illustrated by studies of mouse bone-marrow and spleen cells in the presence or absence of cyclophosphamide, this depot method of BrdU administration greatly simplifies in vivo analysis of sister-chromatid-exchange formation.
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