Structural and functional aspects of P‐glycoproteins and related transport proteins
作者:
Pierre,
Lepage Philippe,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 1993)
卷期:
Volume 2,
issue 5
页码: 735-743
ISSN:1062-4821
年代: 1993
出版商: OVID
数据来源: OVID
摘要:
The emergence of multidrug resistance in tumor cells is caused by the expression of P-glycoprotein. P-glycoprotein has a unique structure formed by two homologous halves, each encoding six putative transmembrane segments and one nucleotide binding fold. This structural arrangement has been conserved in a large number of eukaryotic and prokaryotic membrane transport systems, which together form the ATP binding cassette superfamily. These membrane transporters act on different groups of substrates in different cell types and organisms. The combined molecular analysis of these proteins has shed light on the mechanism by which P-glycoprotein acts on structurally unrelated groups of chemotherapeutic drugs and has allowed the identification of the protein domain responsible for the common mechanism of transport and recognition of substrate molecules. The function of P-glycoprotein in normal tissues remains intriguing and is discussed in this review.
点击下载:
PDF
(890KB)
返 回