Chronic Granulomatous Disease: Mode of Action of Sulfamethoxazole/Trimethoprim
作者:
FELIX GMÜNDER,
REINHARD SEGER,
期刊:
Pediatric Research
(OVID Available online 1981)
卷期:
Volume 15,
issue 12
页码: 1533-1537
ISSN:0031-3998
年代: 1981
出版商: OVID
数据来源: OVID
摘要:
SummaryFour possible modes of action for the clinically observed effectiveness of sulfamethoxazole/trimethoprim in chronic granulomatous disease were evaluated: (1) inhibition of bacterial catalase, (2) improvement of granulocyte oxygen metabolism, (3) synergism of the antibiotic with nonoxygen-dependent granulocyte killing mechanisms, and (4) a purely antibiotic effect based on uptake and concentration of the antibiotic by and within granulocytes.While the first three mechanisms were excluded, the fourth mechanism is highly probable; sulfamethoxazole was found to reach granulocyte associated concentrations 1.7-fold and trimethoprim 4.1-fold of extracellular levels. Penicillin G, a known non-penetrating antibiotic, reached 0.3-fold, and tetracycline, a known penetrating agent, 7.1-fold the extracellular level. These findings indicate that sulfamethoxazole/trimethoprim is an antibiotic combination uniquely suited for the long-term prophylaxis of infections in patients with defects of intracellular phagocyte killing.SpeculationCell permeable antibiotics that concentrate within the acidic granules and vacuoles of phagocytes are likely to be lipid-soluble weak bases.
点击下载:
PDF
(472KB)
返 回