Human T lymphocytes bind to germinal centers of human tonsils via integrin α4/VCAM‐1 and LFA‐1/ICAM−1 and −2
作者:
Folke Schriever,
Dirk Korinth,
André Salahi,
Petja Lefterova,
Ingo G. H. Schmidt‐Wolf,
Susanne I. Behr,
期刊:
European Journal of Immunology
(WILEY Available online 1997)
卷期:
Volume 27,
issue 1
页码: 35-39
ISSN:0014-2980
年代: 1997
DOI:10.1002/eji.1830270106
出版商: WILEY‐VCH Verlag GmbH
关键词: Adhesion;T lymphocyte;Germinal center
数据来源: WILEY
摘要:
AbstractBinding of T lymphocytes within the different compartments of the secondary lymphoid organs is crucial for the function of the cellular and the humoral immune response. It is still not known which adhesion molecules guide T cells to the distinct areas of the lymphoid microenvironment. In the current study anin situadhesion assay was used to define the receptors for binding of T cells to human tonsils. The T cell lines Jurkat and MOLT‐4 and normal, activated T cells were found to bind exclusively to germinal centers. Jurkat cells used the receptor pair integrin‐α4 (VLA‐4α)/VCAM‐1, whereas activated MOLT‐4 cells and normal T cells bound via both adhesion pathways, namely via integrin‐α4/VCAM‐1 and LFA‐1/ICAM‐1 and ‐2. It is suggested that these adhesion mechanisms are involved in the migration of T cells into the germinal centers of secondary lymphoid organs and that they influence the selection o
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