Platelets, endothelial cells and macrophages in the spleen. An ultrastructural study on perfusion‐fixed organs
作者:
Ragna Følling Elgjo,
期刊:
American Journal of Anatomy
(WILEY Available online 1976)
卷期:
Volume 145,
issue 1
页码: 101-119
ISSN:0002-9106
年代: 1976
DOI:10.1002/aja.1001450107
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractRabbit spleens have been examined after perfusion fixation with and without prior washing with various fluids. The platelets were stored in the splenic sinuses and in the cord spaces as single platelets, or in loosley packed aggregates which appeared to be anchored to the endothelium by one or a few platelets. After washing prior to fixation most of the platelets disaggregated and regained their normal shape. Some platelets adhered to morphologically normal endothelium even after prolonged perfusion. Occasionally, platelets were observed inside splenic endothelial cells. Others were closely associated with macrophages, many of which also contained engulfed platelets.There was no morphological evidence of a particular platelet population being retained in the spleen after washing.In the sinuses special granule‐rich cytoplasmic structures were observed. They were interposed between ordinary endothelial cells and contained a large number of small lysosome‐like granules. Nuclei were never observed in these structures, probably because they consisted of pseudopod‐like protrusions. Their origin and function are discussed. They may represent actively phagocytizing ele
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