A reliable method is proposed for simultaneous determination of sulfonylureas in various formulation of commercial products by high performance liquid chromatography. HPLC was achieved on a reverse phase C18column by isocratic elution using water (pH 4.3 with acetic acid) / methanol, and detection was by UV absorption at a wavelength of 254nm. This method has been applied for the quality control of sulfonylurea herbicides in the laboratories of agricultural chemical plants.