SUPPRESSION OF MOUSE SKIN ALLOGRAFT REJECTION BY PROTEIN A-YERSINIAEV ANTIGEN FUSION PEPTIDE1
作者:
Motin2 Vladimir,
Kutas3 Susan,
Brubaker4 Robert,
期刊:
Transplantation
(OVID Available online 1997)
卷期:
Volume 63,
issue 7
页码: 1040-1042
ISSN:0041-1337
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
V antigen is an established virulence factor ofYersinia pestis,the causative agent of bubonic plague. Injection of homogenous staphylococcal protein A-V antigen fusion peptide into mice was previously found to suppress tumor necrosis factor-α and interferon-γ necessary for generation of protective granulomas. Here, we show that BALB/c mice receiving daily intraperitoneal injections of 100 μg of control protein A initiated rejection of C57BL/6 mouse tail skin grafts after 6.2±1.1 days. This time doubled to 12.2±1.4 days upon similar administration of protein A-V antigen fusion peptide (P<0.001); times of total allograft retention remained constant. This finding indicates that V antigen can postpone inflammation known to be associated with recognition and destruction of foreign tissue by T lymphocytes.
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