Potential Role of the Peroxidase-Dependent Metabolism of Serotonin in Lowering the Polymorphonuclear Leukocyte Bactericidal Function
作者:
SalmanSada,
ChristineMarie,
TorreillesJean,
期刊:
Free Radical Research
(Taylor Available online 1996)
卷期:
Volume 24,
issue 1
页码: 61-68
ISSN:1071-5762
年代: 1996
DOI:10.3109/10715769609088000
出版商: Taylor&Francis
关键词: Peroxidase;serotonin;polymorphonuclear leukocytes
数据来源: Taylor
摘要:
Serotonin (5-hydroxytryptamine, 5-HT) significantly and dose-dependently suppressed the luminol-enhanced chemiluminescence (CL) signal generated by polymorphonuclear leukocytes (PMN) activated with phorbol myristate acetate (PMA), but did not modify either lucigenin-enhanced CL or the reduction of super-oxide dismutase-inhibitable cytochrome c. Moreover, stimulation of PMNs previously incubated with 5-HT resulted in a threefold increase in 5-HT equivalents bound to the proteins of PMN. The addition of catalase or sodium azide substantially reduced this binding. The present results suggest that 5-HT metabolism is mediated by H2O2and myeloperoxidase (MPO) released by activated PMNs. Hence 5-HT could lower the bactericidal function of these cells by competition with hypochlorite formation from halides and MPO/H2O2.
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