Analysis of the induction and deinduction of tyrosine aminotransferase in enucleated HTC cells
作者:
R. D. Ivarie,
W. J.‐W. Fan,
G. M. Tomkins,
期刊:
Journal of Cellular Physiology
(WILEY Available online 1975)
卷期:
Volume 85,
issue S1
页码: 357-364
ISSN:0021-9541
年代: 1975
DOI:10.1002/jcp.1040850404
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractAnucleate HTC cells have been used to determine the importance of the nucleus in the regulation of the intracellular levels of tyrosine aminotransferase (TAT) in hepatoma tissue culture (HTC) cells. In the absence of the nucleus, neither the induction of the enzyme by dexamethasone nor its deinduction upon removal of the hormone occurs. Degradation of the enzyme takes place when protein synthesis is inhibited in anucleates by cycloheximide. Therefore, the maintenance of induced levels of enzyme activity after dexamethasone withdrawal from pre‐induced anucleates suggests that the nucleus is required for the inactivation of the TAT mRN
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