The influence of basic fibroblast growth factor on cat corneal endothelial wound healingin vivo
作者:
RichL. F.,
HatfieldJ. M.,
LouiselleI.,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue 8
页码: 719-725
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689209000746
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Using standardized freeze wounds in cat corneas, we tested the efficacy of basic Fibroblast Growth Factor (bFGF) solubilized in phosphate buffered saline (PBS) to promote endothelial healing when injected intraocularly at doses ranging from 0.01µg to 10µg. After 6 days, animals were humanely sacrificed and corneal tissues were fixed and stained for light microscopy and computation of remaining wound areas.A significant dose-response relationship was found between the dosages of 0.01, 0.1, and 1.0 4mUg of bFGF/eye and the stimulation of more completely healed endothelium six days after transcorneal freeze wounding. Significantly larger endothelial wounds were present six days after wounding when the eyes were treated with 10µg of bFGF/eye compared with controls treated with PBS only.
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