Proton NMR relaxation in hydrogel contact lenses: correlation with in vivo lens dehydration data
作者:
LarsenDavid W.,
HuffJoseph W.,
HoldenBrien A.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 7
页码: 697-706
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999586
出版商: Taylor&Francis
数据来源: Taylor
摘要:
A study of hydrogel contact lenses was undertaken to determine whether NMR relaxation data can be used as a predictor for on-eye lens dehydration. Proton NMR relaxation times (T1and T2), were determined for a series of contact lenses for which on-eye dehydration data were also available. NMR relaxation times were found to depend upon lens water content, but the dependence was not monotonic. T1values varied between 100 and 800 msec, and T2values varied between 6 and 85 msec for the lenses studied. In this study, the NMR signal and corresponding relaxation times are average values, derived both from lens water protons as well as from exchangeable polymer protons. A simple analysis of the data indicates that the mobility of these protons varies by more than a factor of 10 for the lenses studied. A test for linear correlation between NMR relaxation rate, 1/T1and relative change in lens water mass, %δmwgave r=-0.830 for all data, and r=0.904 if one lens was excluded.
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