Increased Uptake of Cholesterol and Increased Mineral Content in the Aorta of Long-Term Uremic Rabbits
作者:
Ole Kamstrup,
Erling Tvedegaard,
期刊:
Nephron
(Karger Available online 1983)
卷期:
Volume 33,
issue 4
页码: 267-270
ISSN:1660-8151
年代: 1983
DOI:10.1159/000182966
出版商: S. Karger AG
关键词: Aortic calcifications;Aortic cholesterol;Rabbits;Uremia
数据来源: Karger
摘要:
Chronic renal failure was induced in rabbits by cauterization of one kidney and subsequent contralateral nephrectomy. After 3 and 8 months duration of uremia the 24-hour accumulation rate of radioactive cholesterol into the intima-media part of the thoracic aorta was measured. A significant higher uptake rate was found only in the 8 months uremic rabbits. In these rabbits macroscopic changes of the thoracic aorta were noted with dilatation, increased wall thickness and calcifications. In the 3 months uremic rabbits no morphological changes were seen. In the 8 months group of uremic rabbits the aortic concentration of calcium, phosphate and magnesium was 20-fold increased. In the 3 months group of uremic rabbits only the aortic calcium concentration was significantly increased. In none of the groups was the aortic cholesterol concentration increased. In rabbits long-term uremia induced aortic calcifications and an increased uptake rate of labelled plasma cholesterol but no net cholesterol accumulation could be demonstrated.
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