Neurogenic Regulation of Cerebral Blood Flow Following Ischemia
作者:
NICHOLAS ZERVAS,
HIROSHI HORI,
MAKATO NAGORO,
RICHARD WURTMAN,
期刊:
Stroke
(OVID Available online 1976)
卷期:
Volume 7,
issue 2
页码: 113-118
ISSN:0039-2499
年代: 1976
出版商: OVID
数据来源: OVID
摘要:
To elicit evidence concerning neurogenic control, regional cerebral blood flow determined by measurement of cortical temperature was examined in monkeys. Following three hours of temporary occlusion of the MCA, pressure autoregulation was preserved in all control animals. Presumptive partial chemical sympathectomy, produced by the administration of either L-alphamethyl- tyrosine or 3-alpha-dimethyl-tyrosine methyl ester HCI, was associated with loss of pressure autoregulation following 1.5 hours of occlusion of the MCA on only the side of the occlusion. Failure of pressure autoregulation in the treated animals implies that sympathetic control was a partial requirement of proper postischemic pressure autoregulation.
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