Estrogen-Induced Tetany in Idiopathic Hypoparathyroidism
作者:
P. Burckhardt,
B. Ruedi,
J.P. Felber,
期刊:
Hormone Research in Paediatrics
(Karger Available online 1975)
卷期:
Volume 6,
issue 5-6
页码: 321-328
ISSN:1663-2818
年代: 1975
DOI:10.1159/000178681
出版商: S. Karger AG
关键词: Hypoparathyroidism;Estrogens;PTH;EDTA test
数据来源: Karger
摘要:
A 35-year-old woman experienced tetanic symptoms when treated with chorionic gonadotrophins or estrogenic oral contraceptives. Persistent hypocalcemia was found, with hyperphosphatemia, normal renal function and low normal plasma parathyroid hormone (PTH), all consistent with idiopathic hypoparathyroidism. During EDTA infusion, no PTH response was measured with a predominantly anti-NH2 -terminal antiserum, but a normal response was found with a predominantly anti-COOH-terminal antiserum. This supposes secretion of an immunologically abnormal and biologically ineffective PTH. Oral administration of ethinyl estradiol caused an impressive hypocalcemia with tetanic symptoms. Estrogens might, therefore, inhibit bone resorption by a specific action on bone, and not by antagonizing the action of PTH.
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